Lilya Horbal

Lilya Horbal

Dr., associate research fellow

Department of genetics and biotechnology
Faculty of biological sciences
Ivan Franko National University of L’viv

Phone: +38-032-2394407
Fax: +38-032-2964475

E-mail: lihorbal@gmail.com


Born in 1985

Education:
June 2006 Ms. D. (Faculty of biological sciences, Department of genetics and biotechnology, Ivan Franko National University of L’viv, Ukraine)

28th of December 2010 successfully defended thesis in molecular biology, PhD degree in molecular genetics at the Institute of Molecular Biology and Genetics (Kyiv, Ukraine) under the supervision of Prof. V. O. Fedorenko

Position held:

November 2006 till September 2010 – PhD studying (Department of genetics and biotechnology, Ivan Franko National University of L’viv)
February 2010 till April 2011 – associate research fellow (Department of genetics and biotechnology, Ivan Franko National University of L’viv)
May 2011 till December 2011 postdoctoral stay at  Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
January 2012 – November 2012 – associate research fellow (Department of genetics and biotechnology, Ivan Franko National University of L’viv)
December 2012 till August 2013postdoctoral stay at Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany
August 2013 till now – associate research fellow (Department of genetics and biotechnology, Ivan Franko National University of L’viv

Research Interests

  • Regulation of morphological development and biosynthesis of biologically active compounds in different actinobacteria
  • Search and activation of silent clusters in streptomyces
  • Synthetic biology of biological systems

Selected Publications

  1. Horbal L., Fedorenko V., Bechthold A., Luzhetskyy A. A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis // FEMS Microbiol Lett. 2013 342(2):138-46.
  2. Horbal L., Rebets Yu., Rabyk M., Makitrynskyy R., Luzhetskyy A., Fedorenko V., Bechthold A. SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors // AMB Express – 2012. – Vol. 2:1. – P. 1-12.
  3. Horbal L., Zaburannyy N., Ostash B., Shulga S., Fedorenko V. Manipulating the regulatory genes for teicoplanin production in Actinoplanes teichomyceticus// World J Microbiol Biotechnol. – 2012. – Vol. 28. – P. 2905-2100.
  4. Horbal L., Rebets  Y., Rabyk M., Luzhetskyy A., Ostash B., Welle E., Nakamura T., Fedorenko V., Bechthold A. Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117 // Appl. Microbiol. Biotechnol. – 2010.-Vol.-85-P.1069-1079.
  5.  Rebets Y., Boll R., Horbal (Dutko) L., Fedorenko V., Bechthold A. Production of Avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators // J. Antibiot. – 2009. – Vol.62. – P.461-464.
  6. L. Dutko (L. Horbal), Yu. Rebets, B. Ostash, A. Luzhetskyy, A. Bechthold, T. Nakamura, V. Fedorenko A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912 // FEMS Microbiology letters - 2006.- Vol.255-P.280-285.
  7. Yu. Rebets, L. Dutko (L. Horbal), B. Ostash, A. Luzhetskyy, O. Kulachkovskyy, T. Yamaguchi, A. Bechthold, T. Nakamura, V. Fedorenko Function of lanI gene in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies of Streptomyces Antibiotic Regulatory Proteins encoding genes // Archives of Microbiology – 2007. – Vol.189. – P.111-20.
  8. Gorbal (Dutko) L.O., Rebets U.V., Lughetskyy A., Bechthold A., Fedorenko V.O. Regulation of the simocyclinone biosynthesis in the strain Streptomyces antibioticus Tu6040 with participation of gene simReg1 // Session of Ukrainian genetics “Achievement and problems of genetics, selection and biotechnology”, September 24-28, 2007, Alushta, Ukraine, P. 343-347.
  9.  Fedorenko V.O., Ostash B.O., Lughetskyy A.M., Rebets U.V., Gromyko O.M., Ostash I.S., Klymyshyn D.O., Gorbal (Dutko) L.O., Kobylyanskyy A.M., Myronovskyy M.L. Genetic control of the landomycin E biosynthesis in the strain Streptomyces globisporus 1912 // Session of Ukrainian genetics “Achievement and problems of genetics, selection and biotechnology”, September 24-28, 2007, Alushta, Ukraine, P. 371-376.
  10. Horbal L., Ostash B., Rebets Yu., Rabyk M., Myronovskyy M., Tsypik O., Gromyko O., Ostash I., Luzhetskyy A., Bechthold A., Fedorenko V. Gene networks involved in the regulation of the biosynthesis of polyketides in Streptomyces // Session of Ukrainian genetics “Factors of the experimental evolution of organisms, September 24-29, 2010, Alushta, Ukraine, P. 25-29.
  11. Horbal L.O., Myronovskyy M.L., Rabyk M.V., Makitrynskyy R., Ostash I.S., Grubskyy Ya.P., Klymyshyn D.O., Gren T.P., Tsypik O.V., Lopatnuk M.M., Mutenko G.V., Gromyko O.M., Ostash B.O., Luzhetskyy A.M., Bechthold A., Fedorenko V.O.  Actinomyces regulatory genes: new tools for investigation of the antibiotic biosynthesis and construction of producers // Session of Ukrainian genetics “Achievement and problems of genetics, selection and biotechnology, September 24-28, 2012, Alushta, Ukraine, P. 339-344.