Gromyko Oleksandr Mykolayovych

Gromyko Oleksandr Mykolayovych PhD, research scientist at the laboratory NDL-42
"The genetics, selection and genetic engineering of antibiotic producers"
of Ivan Franko National University of L'viv
Tel.: +38(032)2394407
E-mail: o_gromyko@franko.lviv.ua

Born on 17. 11. 1975 in L'viv
1992-1998 - technician at NDL-42 «The genetics, selection and genetic engineering of antibiotic producers».
1998 - graduated from the Ivan Franko National University of L'viv, Dept. of Genetics and Biotechnology. Diploma of specialist, teacher of biology and chemistry.
1999-2003 - engineer of III, II and I categories.
1999-2004 - secretary-in-chief of the journal «Visnyk of Lviv Univ. Ser. Biol.»
2003-2007 - junior research scientist.
2006 - curator of the Collection of the culture microorganisms - antibiotic producers of Ivan Franko National University of L'viv.
2008 π. defended PhD thesis entitled "Mutations of resistance to antibiotics which influence the biosynthesis of landomycin E in  Streptomyces globisporus 1912-2 and nogalamycin in Streptomyces nogalater IMET43360" (Advisor - Prof. V. Fedorenko).
2008 - research scientist of NDL-42.
2009 - present - senior researcher in the research group of Prof. Victor Fedorenko (NDL-42).
Research interests: development of actinomycete strains that possess high level of production of antibiotics and other biologically active compounds.

Main publications

  1. Raju R., Gromyko O., Butsiak A., Fedorenko V., Luzhetskyy A., Muller R. Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp. //  J. of Antibiotics. – 2014. –Vol. 67. – P. 339-343. doi:10.1038/ja.2014.1. PMID: 24448627.
  2. Raju R. Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp. //  J. of Antibiotics. – 2014. –Vol. – P.  2014 Oct 1. doi: 10.1038/ja.2014.138. PMID: 25269463.
  3. Gromyko O. Antagonistic properties of actinomycetes isolated from the rhizosphere celandine Chelidoniummajus L. // Visnyk of the Lviv University. Series BIology. – 2014. Is.64. – P. 279–286.
  4. Raju R., Gromyko O., Fedorenko V., Herrmann J., Luzhetskyy A., Muller R. Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp //Tetrahedron Letters. – 2013. – Vol. 54, Is. 8. – P. 900–902.
  5. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R.  Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. // J. of Antibiotics. – 2013. – Vol. 66. – P. 347-349 doi:10.1038/ja.2013.18.
  6. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R.  Oleaceran: A Novel Spiro[isobenzofuran-1,2'-naptho[1,8-bc]furan] Isolated from a Terrestrial Streptomyces sp. // Organic Lett. – 2013. – Vol. 15, Is.14. – P. 3487-3489. doi: 10.1021/ol401490u.
  7. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Plaza A., Muller R.  Juniperolide A: A New Polyketide Isolated from a Terrestrial Actinomycete, Streptomyces sp. // Organic Lett. – 2012. – Vol. 14, Is. 23. – P. 5860–5863. DOI: 10.1021/ol302766z.
  8. Gromyko O. Antagonistic properties of actinomycetes from the ryzosphere of Olea europaea L. – Visn. Lviv Univ. Ser. Biol.  – 2012. – Vol. 59. – P. 209-215.
  9. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Pimprinols A–C, from the terrestrial actinomycete, Streptomyces sp. / // Tetrahedron Letters. – 2012. – Vol. 53, Is. 24. – P. 3009–3011.
  10. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Leopolic acid A, isolated from a terrestrial actinomycete, Streptomyces sp. – Tetrahedron Letters. – 2012. – Vol. 53, Is. 46. – P. 6300–6301.
  11. Klimishin D.A. Rabyk M.V., Gren' T.P., Nimets' O.Ya., Gonchar M.A., Gromyko A.N., Fedorenko V.A. Design of Streptomycesnogalater LV65 strains with higher synthesis of nogalamicin using regulatory genes. Appl. Biochem. Microbiol. – 2011. – Vol. 47, No. 6. – Π. 594–598.
  12. Gromyko O. Antifungal and antibacterial properties of Actinomyces strains isolated from the rhizosphere of  Juniperus excelsa Bieb. – Visn. Lviv Univ. Ser. Biol.  – 2010. – Vol. 53. – P.156-160.
  13. Gromyko O., Yu. Rebets, B. Ostash, A. Luzhetskyy, M. Fukuhara, A. Bechthold, T. Nakamura, V. Fedorenko Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization// J. Antibiot., 2004. Vol.57, N6, P.383-389.
  14. Gromyko Ξ., Fedorenko V. Influence of the mutagens on antibiotic activity of Streptomycesnogalater IMET43360 - producer of antitumor antibiotic nogalamycin. Visn. Lviv Univ. Ser. Biol.  2005. V.40. P.16-22.
  15. Ostash B., U. Rix, L. Remsing-Rix, T.Liu, F. Lombo, A. Luzhetskyy, Gromyko Ξ., C. Wang, A. F. Brana, C. Mendez, J. A. Salas, V. Fedorenko, and J. Rohr. Generation of new landomycins by combinatorial biosynthetic manipulation of the lndGT4 gene of the landomycin E cluster in S. globisporus // Chem. Biol.- 2004.-Vol 11.-P. 547-555.
  16. Gromyko Ξ., Kirichenko N.V., Fedorenko V. Streptomyces nogalater IMET43360 mutants with increased level of biosynthesis of antitumor antibiotic nogalamycin // Visn. Lviv Univ. Ser. Biol. 2004. V.35 P.121-127.
  17. Sydorov U., Fedorenko V., Gromyko O., Novykov V., Vliazlo R., Veres R., The calculation model of antitumor antibiotic landomycin E production // Lviv Polytechnic Univ. J. – 2002. – Vol. – 461. – P. 204-208.
  18. Gromyko O., Basilia L., Kyrychenko N., Fedorenko V. Obtaining and characterization of streptomycin-resistant mutants of Streptomyces globisporus 3-1, the producer of antitumor antibiotic landomycin E // Visnyk of Lviv University. Ser. Biol. – 2000. – Vol 26. – P. 46-53.