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: +038-032-2394768, +038-032-2394407
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: v_fedorenko@lnu.edu.ua



1951 . 1973 1979 - - (). 1981 " Strepomyces coelicolor A3(2)" ( - . ..), 2005 - 㳿 () " ".

1979 㳿 . 1985 . 㳿 1994 . , () 㳿 (ɺ, ).

"" , " ", " ". " , 㳿 " (2007 ) " " (2008 ). ³ (2011 ). 1995 1997 . ϳ 30 - , 17 1 . .. 370 18 . "Natural products via enzymatic reactions", "Topics in Current Chemistry." (Vol. 297) Springer-Verlag (2010).

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. http://www.ncbi.nlm.nih.gov/pubmed/?term=Fedorenko+V


2010-2015 :

  1. Lopatniuk M., B. Ostash, R. Makitrynskyy, S. Walker, A. Luzhetskyy, V. Fedorenko. Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672 // J. Appl. Genetics -2015 March 24 [Epub ahead of print]; DOI: 10.1007/s13353-015-0283-8 Available from: http://link.springer.com/article/10.1007/s13353-015-0283-8
  2. Klymyshin D.A., Stefanyshyn O.N., Fedorenko V.A. Role of genes snoaM, snoaL, and snoaEin the biosynthesis of nogalamycin inStreptomyces nogalaterLv65. Cytology and Genetics 2015. Vol.49, Is.3. - P. 152 157. DOI10.3103/S0095452715030081
  3. Raju R., O. Gromyko , V. Fedorenko, A. Luzketskyy, R. Muller. Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp. J. Antibiot. . 2015, Vol.68(4):286-8. doi: 10.1038/ja.2014.138.
  4. Horbal L., Kobylyanskyy A., Truman A.W., Zaburranyi N., Ostash B., Luzhetskyy A., Marinelli F., Fedorenko V. The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus. Appl. Microbiol. Biotechnol. 2014, Vol. 98, Is. 22. P. 92959309. doi:10.1007/s00253-014-5969-z.
  5. Horbal L., Fedorenko V., Luzhetskyy A. Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria. Appl. Microbiol. Biotechnol. 2014, Vol. 98, Is. 20. P.86418655. doi:10.1007/s00253-014-5918-x.
  6. Mutenko H., R. Makitrinskyy, O. Tsypik, S. Walker, B. Ostash, V. Fedorenko. Genes for biosynthesis of butenolide like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production. Rus. J. Genetics 2014. Vol. 50, No. 6. . 563568.
  7. Lopatniuk M., B. Ostash, A. Luzhetskyy, S. Walker, V. Fedorenko. Generation and study of the strains of streptomycetes - heterologous hosts for the production of moenomycin. Rus. J. Genetics 2014. Vol. 50, No. 4. . 360365.
  8. Rabyk M.V., Ostash B.O., Fedorenko V.O. Gene networks that regulate secondary metabolism in actinomycetes: pleiotropic regulators. // Cytology and Genetics 2014 Vol. 48, N.1. Vol. 5567. doi:10.3103/S0095452714010083. PMID:24791475.
  9. Ostash B., Shashkov A., Streshinskaya G., Tul'skaya E., Baryshnikova L., Dmitrenok A., Dacyuk Y., Fedorenko V. Identification of Streptomyces coelicolor M145 genomic region involved in biosynthesis of teichulosonic acid-cell wall glycopolymer. Folia Microbiol. 2014 Vol.59, N4 P. 355360. doi: 10.1007/s12223-014-0306-6. PMID:24526589.
  10. Zaburannyi N., Rabyk M., Ostash B., Fedorenko V., Luzhetskyy A. Insights into naturally minimised Streptomyces albus J1074 genome. BMC Genomics. 2014 5;15:97. doi: 10.1186/1471-2164-15-97. PMID:24495463.
  11. Raju R., Gromyko O., Butsiak A., Fedorenko V., Luzhetskyy A., Muller R. Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp. J. Antibiot. 2014. Vol. 67, N.4. P. 339343. doi: 10.1038/ja.2014.1. PMID:24448627.
  12. Gren T., Ostash B., Hrubskyy Y., Tistechok S., Fedorenko V. Influence of transition metals on Streptomyces coelicolor and S. sioyaensis and generation of chromate-reducing mutants. Folia Microbiol. 2014. Vol.59, N2. P. 147153. doi: 10.1007/s12223-013-0277-z. PMID:24037512.
  13. Ostash B., Gren T., Hrubskyy Y., Tistechok S., Beshley S., Baranov V., Fedorenko V. Cultivable actinomycetes from rhizosphere of birch (Betula pendula) growing on a coal mine dump in Silets, Ukraine. J. Basic Microbiol. 2014. Vol. 54, N.8. P. 851 857. doi: 10.1002/jobm.201200551. PMID:23686352.
  14. Klymyshin D.O., Nimets O.Ya., Stefanyshyn O.M., Fedorenko V.O. Heterologeus expression of lndYR and wblAgh genes in producers of anthracyclin antibiotics Streptomyces nogalater Lv65, S. echinatus DSM40730 and S. peucetius subsp. caesius ATCC27952. Cytology and Genetics. 2013. Vol. 47, Issue 4. P. 3 8.
  15. Makitrynskyy R., Ostash B., Tsypik O., Rebets Y., Doud E., Meredith T., Luzhetskyy A., Bechthold A., Walker S., Fedorenko V. Pliotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol. 2013. 3(10):130121. doi:10.1098/rsob.130121
  16. Horbal L., Kobylyanskyy A., Yushchuk O., Zaburannyi N., Luzhetskyy A., Ostash B., Marinelli F., Fedorenko V. Evaluation of heterologous promoters for genetic analysis of Actinoplanes teichomyceticus - producer of teicoplanin, drug of last defense. J Biotechnol. - 2013 Vol.168, N 4. P. 367 372. doi: 10.1016/j.jbiotec.2013.10.018.
  17. Ostash B., Ostash I., Horbal L., Fedorenko V. Exploring and exploiting gene networks that regulate natural products biosynthesis in Actinobacteria. Nat. Prod. J. 2013. Vol. 3, N. 3. - P: 189 198.
  18. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Oleaceran: A novel spiro[isobenzofuran-1,2'-naptho[1,8-bc]furan] isolated from a terrestrial Streptomyces sp.Organic Lett. 2013 Jul 19;15(14):3487 - 3489. doi: 10.1021/ol401490u..PMID:23802119.
  19. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. J. Antibiot. - 2013. Jun; Vol. 66, N 6. P. 7 - 9. doi: 10.1038/ja.2013.18. Epub 2013 Apr 3. PMID:23549352
  20. Horbal L., Fedorenko V., Bechthold A., Luzhetskyy A. A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS Microbiol. Lett. - 2013 May; - Vol. 342, N 2. P.:138 - 146. doi: 10.1111/1574-6968.12117. PMID:23480614.
  21. Klimishin D.A., Rabyk M.V., Fedorenko V.A. Nogalose methylation in the nogalamycin biosynthesis in Streptomyces nogalater LV65. Mikrobiologiia. 2013. - Vol. 82, N2. P. 162 168.
  22. Tsypic O., Ostash B., Rebets Yu., Fedorenko V. Caracterization of the Streptomyces globisporus 1912 lnd-cluster region containing the lndYlndYR,lndW2, and lndW genes. Cytology and Genetics. 2013. Vol. 47, No. 1. P. 8 12.
  23. Raju R., Gromyko O., Fedorenko V., Herrmann J., Luzhetskyy A., Muller R. Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp. - Tetrahedron Lett. 2013. Vol. 54, Is. 8. P. 900 -902.
  24. Raju R., Gromyko O., Fedorenko V.Luzhetskyy A., Plaza A., Muller R. Juniperolide A: a new polyketide isolated from a terrestrial actinomycete, Streptomyces sp. Organic Lett.  2012. Vol. 14, N. 23. P. 5860 5863.
  25. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Lepolic acid A, isolated from terrestrial actinomycete, Streptomyces sp. Tetrahedron Lett. 2012. Vol. 53, Is. 46. 6300 6301.
  26. Shashkov A.S., Ostash B.E., Fedorenko V.A., Streshinskaya G.M., Tul'skaya E.M., Senchenkova S.N., Baryshnikova L.M., Evtushenko L.I. Novel teichulosonic acid from cell wall of Streptomyces coelicolor M145. Carbohydr. Res. 2012. Vol. 359. P. 70-75.
  27. Horbal L., RebetsY., Rabyk M., Makitrynskyy R., Luzhetskyy A., Fedorenko V., Bechthold A. SimReg1 is a master swich for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express 2012, 2:1.
  28. Horbal L., Zaburannyy N., Ostash B., Shulga S., Fedorenko V. Manipulating the regulatory genes for teicoplanin production in Actinoplanes teichomyceticus. World J. Microbiol. Biotechnol., 2012. Vol. 28. P. 2095 2100.
  29. Raju R., Gromyko O., Fedorenko V., Luzhetskyy A., Muller R. Pimprinols A-C, from terrestrial actinomycete, Streptomyces sp. Tetrahedron Lett. 2012. Vol. 53, Is. 24. 3009 3011.
  30. Ostash B., Rebets Y., Myronovskyy M., Tsypik O., Ostash I., Kulachkovskyy O., Datsyuk Y., Nakamura T., Walker S., Fedorenko V. Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production. Microbiology. 2011. Vol.157. 1240 1249.
  31. Myronovskyi M. Welle E., Fedorenko V., Luzhetskyy A. Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl. Environ. Microbiol. 2011. Vol.77, Is.15. P. 54205427.
  32. Rabyk M. B. Ostash, Y. Rebets, S. Walker, V. FedorenkoStreptomyces ghanaensis pleiotropic regulatory gene wblAgh influences morphogenesis and moenomycin production. Biotechnol. Lett. 2011. Aug 21. DOI 10.1007/s10529-011-0728z.
  33. Klimishin D.A. Rabyk M.V., Gren' T.P., Nimets' O.Ya., Gonchar M.A., Gromyko A.N., Fedorenko V.A. Design of Streptomyces nogalater LV65 strains with higher synthesis of nogalamicin using regulatory genes. Appl. Biochem. Microbiol. 2011. Vol. 47, No. 6. . 594598.
  34. Klymyshin D.O., Gren T.P., Fedorenko V.O. Role of the snorA gene in nogalamycin biosynthesis by strain Streptomyces nogalater Lv65. Microbiology (Moscow), 2011, Vol. 80, No. 4, pp. 496501.
  35. Ostash B., Yan X., Fedorenko V., Bechthold A. Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Top. Curr. Chem. "Natural products via enzymatic reactions". Ed. J. Piel. Springer-Verlag Berlin Heidelberg : 2010. - Vol. 297. - P. 105148.
  36. Ostash B., Doud E., Fedorenko V. The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases. Biol Chem. 2010. Vol.391, N5. P.499 504.
  37. Ostash B., Ostash I., Zhu L., Kharel M.K., Luzhetskyy A., Behthold A., Walker S., Rohr J., Fedorenko V. Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus. Rus J Genet.- 2010. Vol.46,N5.- P.530-535. [pdf, 347Kb]
  38. Myronovskyy M.L., Ostash B.E., Fedorenko V.A. Diversity of genes encoding nonribosomal peptide synthetases in the Streptomyces sioyaensisgenome. Rus J Genet. 2010. Vol.46, N7. - P.791-797.
  39. Makitrynskyy R., Rebets Y., Ostash B., Zaburannyi N., Rabyk M., Walker S., Fedorenko V. Genetic factors that influence moenomycin production in streptomycetes. J Ind Microbiol Biotechnol. 2010. Vol.37, N6.- P.599-566.
  40. Horbal L., Rebets Y., RabykM., Luzhetskyy A., Welle E., Ostash B., NakamuraT., Fedorenko V., Bechthold A. Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tu117 // Appl. Microbiol. Biotechnol. 2010. Vol.85,N4. P.1069-1079.

 


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